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The AF-S DX NIKKOR 18-300mm f/3.5-6.3G ED VR Lens (Model 2216) is compatible with the D850. However, this is a DX format lens and is optimized for use on DSLRs with the smaller DX sensor. When a DX lens is used on an FX camera, like the D850, the camera will switch over to DX Crop Mode. In DX crop mode the D850's largest available Image Size is reduced to 5,408 x 3,600 (19.4 Megapixels). FX format lenses would be a better choice for the D850. For an FX format lens with a similar zoom range consider the AF-S NIKKOR 28-300mm f/3.5 -5.6G ED VR Lens (Model 2191).
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