Yes you absolutely can. I've had a Samsung S8 PLUS and now have a S20 5G and they both charge while in an Otterbox Defender (Pro?) BUT!! Apparently, when you get to the last few percent of the charge the charger lowers the voltage and it makes it so the phone has to be on it's side and centered perfectly on the charger. If you don't care about the last 2 or 3 % then don't worry about it.
Another but. I just bought from Amazon one of the those magnetic chargers that comes with three cords and a bunch of "Tips". You plug in a tip in your phone or whatever and just leave it there. Then when you want to charge the phone, you take the L.E.D. lit up end of the cable (Totally cool and easier to find) and just get the phone near the end and it "Sucks" itself right on the "Tip" that you always leave in your phone. It's VERY, VERY Cool!!!!
I'm getting ready to buy a wireless charger that you lay your phone on. I'm thinking that way it won't matter which way the phone is turned. We'll see. I flippen' just love all these gadgets. It's a great time to be alive. I don't need two different charging systems but it's nice to have them all over the house so you can just lay the phone down anywhere and it's charging.