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Hi David! Thank you so much for reaching out to us. Yes, the Pioneer DMH-2660NEX and DMH-W4660NEX are compatible with the factory Bose amplifier in a 2005 Silverado. However, you may need an interface to retain certain functions such as steering wheel controls, OnStar, and factory amplifier integration. Some commonly used interfaces for this type of installation are the PAC RP5-GM11 or the Metra Axxess GMOS-04. It is recommended to consult with BestBuy's AutoTech team at 1-888-237-8289. JC | Pioneer Support
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