A:Answer It would most likely work, but it seems like the b450 tomahawk only has 1 gen3 M.2 slot. Since this is a PCIE gen 4 drive, you would be limited to the bandwidth of the slot. It would be a better Idea to go with a cheaper, PCIE Gen 3 SSD such as the 970 Evo, because you would get similar performance for a lower price in this situation. If you need the increased bandwidth of a PCIE gen 4 SSD, You would need to upgrade your motherboard to one that supports PCIE gen 4 and make sure that your CPU supports gen 4 as well.