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Hi Strider! Thank you for raising this question to us. Yes, the Toshiba 50" Class C350 Series LED 4K UHD Smart Fire TV should support IR for your infrared BOSE audio system. You should be able to control your audio system with the TV remote. JC | Toshiba Support https://www.bestbuy.com/site/toshiba-50-class-c350-series-led-4k-uhd-smart-fire-tv/6525243.p?skuId=6525243
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