A:AnswerIt can be used with a speck case but it was only be used with some otter box cases. I would not recommend anyone to use it with the otter box defender case but you can use it with the symmetry ones and commuter ones.
A:AnswerYes, in fact I just purchased an otter box defender for my iPhone 5s and the glass fits perfectly. Just make sure you choose the right glass for whatever phone you have. Of course both parts of your case will need to come off before application.
A:AnswerIt may help protect the screen from further damage. However, we recently did the same thing (I really don't recall the brand of the product we used) for a serverly cracked front screen and the protecting screen also broke in day to day use. I would point out that the phone screen was very severely cracked (shattered).