A:Answer Yes, you can do so with macros. Keystrokes are supposed to be the method for changing the side buttons, but for some reason they don't work properly. I've scoured the internet for any solution, but found none. There was a video on YouTube from a small tech channel where the guy went through the issues with it. He had called the Dell tech support and even they couldn't figure their own product out...lol
Long story short: use the macro setting to create a macro for the side buttons, e.g., I have one of my side buttons tied to semicolon on the keyboard. The key is to fiddle with the "delay" option a bit until you hit the sweet spot. I couldn't get it to work well with something like push to talk, or anything else that requires you do constantly hold it down. Toggle works well though. So I use push to mute for Discord, for example.
Hope this helps! Look for that YouTube video!