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You can populate both slots, however please note that with the bottom slot in use SATA ports 5 and 6 will be disabled. https://rog.asus.com/motherboards/rog-strix/rog-strix-z490-e-gaming-model/spec
Sorry, there was a problem. Please try again later.HD with your OS goes on the top and your non-OS goes on the bottom. You will have to remove video card and possibly cpu cooler to get to top m2.
Sorry, there was a problem. Please try again later.Also be sure to change the bios M.2 setting to PCIE, it defaults to SATA on M2_1 which appears to affect M2_2 too. After I installed my SN750 500GB in that slot, the WD app was reporting only 2 lanes. Once I tweaked that setting, it came up to 4x (lanes), which is its full capability.
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