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The 251's are the small ink cartridges, cyan, magenta, yellow, and small black. The 250 is the large black.
Sorry, there was a problem. Please try again later.Both cartridges are to be installed on the printer. It’s not your choice. When you use the printer it determines which will be used. It seems likely though I cannot prove it that the 250 is used by the printer when a large amount of black is to be used such as printing letters and documents. The 251 is probably ink source for photos.
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