A:AnswerI haven't personally used HTRF sound in CS:GO but I have used the 7.1 feature and love it. If you don't want to use it is very easy to turn off in the CUE software. You just click a button the boom back to HTRF.
A:AnswerI'm assuming you are referring to skype calls. As long as whatever device your using for calls has a USB input, you should be fine. There's a mic volume issue that you should look up before purchase.