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I'm not sure on full size, but the case looks big enough. The Mobo that's in it barely takes up over half of the height and it seems about the standard size case of any normal computer i've seen so i'm sure it can. For reference, there are still about 3.5 slots left in the back (where the graphics card pciexpress ports would open out to the back not sure of the proper name) of the computer that the mobo doesn't go past for room to expand. Seems to have room for about 11inches wide by 12 inches high for a mobo.
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