I did that once. Yes. It dries up, not the ink in the tank, but the nozzles, and it's a pain in the behind to get everything working again. I had to do the nozzle cleaning function about 30 times to get it going again correctly. But it did recover. I usually print at least 100 pages a month between art prints and homeschool projects but I took and month off, which I wont do again!!