My preferred method is to go into picture setting while each type of playback is live. Calibrate 4k through picture setting while 4k content is live. Same with HDR, etc. I typically calibrate for the brightest possible room conditions. If you calibrate at night, it will end up being too dark during the day. You can use the automatic light sensor, but I find that it's not consistent. My preference is to go brighter and lock it in. I'm sure others have varying opinions on this.