A:Answer No. Not without popping out the window case and replacing it with a plywood or Plexiglas. For the amount of cooling this unit does and the price it is, its not worth going to that much trouble. If you are going to remove the crank window to accommodate an upright air conditioner, in my opinion you would be better off installing a window unit since you lost the advantage of wheeling this from room to room, and upright air conditioners are not very efficient anyways.