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Yes it will control the Yamaha RX-385, once programmed you will push the devices button it will list all the devices that you programmed in to the remote.
Sorry, there was a problem. Please try again later.Hello Dale. The 665 will be able to control most, if not all, aspects of your Yamaha receiver. It can switch inputs, adjust volume and most other settings. For compatibility, check here: https://support.myharmony.com/en-us/compatibility
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