A:Answer Yes. When you're setting it up in the Logitech software on your computer, you can have multiple brands and models of up to 10 devices. You will then assign the devices to various "activities" that use a particular device. So, if your goal is to have 1 remote to control several TVs, this will do that. You'll just have to remember it is a line-of-site remote, so you'll need to take it with you to the room where the device you want to control is.
Hope this helps.