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No, the AF-P DX NIKKOR 70-300mm f/4.5-6.3G ED Telephoto Zoom Lens will not be compatible with the Nikon D300s. AF-P type lenses are not compatible with this camera as they use a new type of electromagnetic focus system that the D300s cannot communicate with. The D300s will be compatible with AF and AF-S type lenses with apertures of D and G.
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