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Hello there, Yes, you can use Affresh in your Samsung washing machine when you run the "Self Clean" cycle on the unit. For guidelines, please refer to page 46 of the manual link below. User manual https://downloadcenter.samsung.com/content/UM/202407/20240725162513128/DC68-03850D-07_IB_WA3200T_EN.pdf Have a lovely day. -Kimberly
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