A:Answer Yes, you can use it with Amazon Fire TV box (second generation). The image will be amazing but the sound will be a problem, once the Amazon Fire TV (second generation) hasn't an optical sound output anymore, and if you connect via HDMI the sound output will be a 5.2 reproducing badly the surround 5.1. For me it is just a stereo sound in 5 speakers. No deep bass, no surround sound, just stereo...pretty much frustrating.