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Yes it will, you should only need the necessary screw driver to replace the drives. I would ensure the cable connecting the Hard Drive to the computer is SATA 3 to get the most out of your SSD. please use this reference if you need some suggestions on what to do. https://www.crucial.com/usa/en/compatible-upgrade-for/Gateway/dx4860
Sorry, there was a problem. Please try again later.Yes, this will work with the gateway dx4860 Desktop, you may need an SSD mounting bracket?
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