After a ton of research etc. I have the VIZIO P65 F1 set as follows. Picture Mode VIVID: Auto Brightness Off, Back light 26, Brightness 30, Contrast 65, Color 60, Tint 0, Sharpness 30, Color Temp Cool, Black detail Low, Extreme Black Engine Pro Low. Reduce Judder 0, Reduce Motion Blur 0, Clear Action Off, Reduce signal noise Low, Reduce Block Noise, Low, Game Low Latency Off, Film Mode On, Color Space Auto, Gamma 2.2
I find these setting the best for all platforms, Cable, UHD, 4k ,Sports and gaming. One Caveat, the TV is not in a brightly lit room, it's in our finished basement with virtually no sunlight entering the room, but we do have ample ceiling lighting and our viewing distance is about 15 feet. Hope this helps!