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Best Buy customers often prefer the following products when searching for left handed optical mouse.

A mouse is one of the most important peripherals for your computer, and there are a lot of different options out there. If you're left-handed, it can be hard to find a mouse that feels natural and works well for you. Fortunately, we have just the products that can help you. Browse the top-ranked list of left-handed optical mice below along with associated reviews and opinions.

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  1. Prestige - Handshoe Wireless Left-Handed BlueTrack Mouse - Black - Front_Zoom

    Product Description

    Prestige Handshoe Wireless Mouse: Navigate features on your PC or Mac without experiencing gripping force, pinching and finger stretching when you use this ergonomic wireless mouse, which features a left-handed Light Click design with full hand support for lasting comfort.
    See all Wireless & Bluetooth Mice

    Product Description

    Prestige Handshoe Wireless Mouse: Navigate features on your PC or Mac without experiencing gripping force, pinching and finger stretching when you use this ergonomic wireless mouse, which features a left-handed Light Click design with full hand support for lasting comfort.
    See all Wireless & Bluetooth Mice
    See all Wireless & Bluetooth Mice
  2. Logitech - M240 Silent Wireless Ambidextrous Mouse - Graphite - Front_Zoom
    Top comment

    "I bit small more my hand, with tiny lag here and there, but so far its better then the other mice ive had....Logitech mouse...Great mouse for the price. It's Bluetooth and it works great whether you put it on the left, right, or anywhere."

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    Product Description

    Meet the reliable Logitech M240 Silent Bluetooth Mouse that frees up your workspace. Pair and play with a fast, easy Bluetooth wireless connection; just seconds and you’re connected—no dongle or port required. Ultra quiet-mouse with 90% reduced click sound and same click feel eliminates noise and distractions for you and others around you. 18-month battery life with auto sleep, so you go longer between battery changes. Comfortable, travel-friendly slim mouse is small enough to toss in a bag; the ambidextrous design guides either your right or left hand into a natural position.
    See all Wireless & Bluetooth Mice
    Top comment

    "I bit small more my hand, with tiny lag here and there, but so far its better then the other mice ive had....Logitech mouse...Great mouse for the price. It's Bluetooth and it works great whether you put it on the left, right, or anywhere."

    See all customer reviews

    Product Description

    Meet the reliable Logitech M240 Silent Bluetooth Mouse that frees up your workspace. Pair and play with a fast, easy Bluetooth wireless connection; just seconds and you’re connected—no dongle or port required. Ultra quiet-mouse with 90% reduced click sound and same click feel eliminates noise and distractions for you and others around you. 18-month battery life with auto sleep, so you go longer between battery changes. Comfortable, travel-friendly slim mouse is small enough to toss in a bag; the ambidextrous design guides either your right or left hand into a natural position.
    See all Wireless & Bluetooth Mice
    See all Wireless & Bluetooth Mice
  3. Logitech - Lift Left Vertical Wireless Ergonomic Left-Handed Mouse with 4 Customizable Buttons - Graphite - Front_Zoom
    Top comment

    "Great Left handed mouse...love the option to have a Left-handed mouse! Finally jumped.. and make the purchase....Reliable comfortable left handed mouse....Got it after injuring my right wrist to switch to left handed mousing. It does what it says on the box - its an ergonomic left handed mouse. "

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    Product Description

    Desk life getting you down? Lift yourself up with Lift Vertical Ergonomic Mouse – a comfy and intuitive wireless mouse with quiet clicks crafted specially for small-to-medium hands. Available in right and left. Lift’s unique 57-degree angle elevates your wrist to give a feeling of relief — and sends a wave of comfort through the forearm and upper body. Scrolling feels second nature with SmartWheel, which easily shifts from precision to speed-scroll. Customize Lift ergo mouse using intuitive Logi Options+ Software.
    See all Wireless & Bluetooth Mice
    Top comment

    "Great Left handed mouse...love the option to have a Left-handed mouse! Finally jumped.. and make the purchase....Reliable comfortable left handed mouse....Got it after injuring my right wrist to switch to left handed mousing. It does what it says on the box - its an ergonomic left handed mouse. "

    See all customer reviews

    Product Description

    Desk life getting you down? Lift yourself up with Lift Vertical Ergonomic Mouse – a comfy and intuitive wireless mouse with quiet clicks crafted specially for small-to-medium hands. Available in right and left. Lift’s unique 57-degree angle elevates your wrist to give a feeling of relief — and sends a wave of comfort through the forearm and upper body. Scrolling feels second nature with SmartWheel, which easily shifts from precision to speed-scroll. Customize Lift ergo mouse using intuitive Logi Options+ Software.
    See all Wireless & Bluetooth Mice
    See all Wireless & Bluetooth Mice
  4. Logitech - G502 X Wired USB Gaming Mouse with HERO 25K Sensor - White - Front_Zoom
    Top comment

    "Excellent mouse...The Logitech G502 X wired mouse (white) is excellent as a productivity mouse. ...This is the best mouse I’ve ever used the mouse scroll click left/right is amazing and rivaled by none"

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    Product Description

    G502 X, the latest version of Logitech’s most popular gaming mouse, combines a legacy of performance with the most advanced gaming technologies. G502 X also introduces hybrid optical-mechanical LIGHTFORCE switches for the primary left and right buttons. With HERO 25K sub-micron sensor, reversible and removable DPI-shift button, redesigned scroll wheel with dual hyper-fast and precise ratchet modes, thin-wall molding and lightweight design.
    See all Gaming Mice
    Top comment

    "Excellent mouse...The Logitech G502 X wired mouse (white) is excellent as a productivity mouse. ...This is the best mouse I’ve ever used the mouse scroll click left/right is amazing and rivaled by none"

    See all customer reviews

    Product Description

    G502 X, the latest version of Logitech’s most popular gaming mouse, combines a legacy of performance with the most advanced gaming technologies. G502 X also introduces hybrid optical-mechanical LIGHTFORCE switches for the primary left and right buttons. With HERO 25K sub-micron sensor, reversible and removable DPI-shift button, redesigned scroll wheel with dual hyper-fast and precise ratchet modes, thin-wall molding and lightweight design.
    See all Gaming Mice
    See all Gaming Mice
  5. Logitech - G502 X LIGHTSPEED Wireless Gaming Mouse with HERO 25K Sensor - White - Front_Zoom
    Top comment

    "Amazing PC Gaming Mice...Amazing gaming mouse! Extremely customizable and user-friendly, interface to customize action buttons. ...Grea wireless mouse...I have a few mice i use depending on the situation, this one is a great overall one, the multiple profiles alows working with multiple programs with no problem, i used it for gaming and it behave well, if you position the adapter at a proper distance, you cant feel a diference from a wired mouse, great overall"

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    Product Description

    G502 X LIGHTSPEED, the latest version of Logitech’s most popular gaming mouse, combines a legacy of performance with the most advanced gaming technologies. G502 X also introduces hybrid optical-mechanical LIGHTFORCE switches for the primary left and right buttons. Complete with updated LIGHTSPEED wireless with 68 percent faster response rate, HERO 25K sub-micron sensor, reversible and removable DPI-shift button, redesigned scroll wheel with dual hyper-fast and precise ratchet modes, thin-wall molding and lightweight design, optimized battery lasting for up to 140 gaming hours, and more.
    See all Gaming Mice
    Top comment

    "Amazing PC Gaming Mice...Amazing gaming mouse! Extremely customizable and user-friendly, interface to customize action buttons. ...Grea wireless mouse...I have a few mice i use depending on the situation, this one is a great overall one, the multiple profiles alows working with multiple programs with no problem, i used it for gaming and it behave well, if you position the adapter at a proper distance, you cant feel a diference from a wired mouse, great overall"

    See all customer reviews

    Product Description

    G502 X LIGHTSPEED, the latest version of Logitech’s most popular gaming mouse, combines a legacy of performance with the most advanced gaming technologies. G502 X also introduces hybrid optical-mechanical LIGHTFORCE switches for the primary left and right buttons. Complete with updated LIGHTSPEED wireless with 68 percent faster response rate, HERO 25K sub-micron sensor, reversible and removable DPI-shift button, redesigned scroll wheel with dual hyper-fast and precise ratchet modes, thin-wall molding and lightweight design, optimized battery lasting for up to 140 gaming hours, and more.
    See all Gaming Mice
    See all Gaming Mice
  6. Logitech - G502 X LIGHTSPEED Wireless Gaming Mouse with HERO 25K Sensor - Black - Front_Zoom
    Top comment

    "If something like that won't bother you, it's an EXCELLENT mouse and probably 5 stars! No worries about double clicking with the optical switches, long battery life, and a great shape (fit my hands like a glove)....The last mouse youll buy...I swapped out various mice this year between the pro & x 903 this is the most comfortable mouse ive ever bought. "

    See all customer reviews

    Product Description

    G502 X LIGHTSPEED, the latest version of Logitech’s most popular gaming mouse, combines a legacy of performance with the most advanced gaming technologies. G502 X also introduces hybrid optical-mechanical LIGHTFORCE switches for the primary left and right buttons. Complete with updated LIGHTSPEED wireless with 68 percent faster response rate, HERO 25K sub-micron sensor, reversible and removable DPI-shift button, redesigned scroll wheel with dual hyper-fast and precise ratchet modes, thin-wall molding and lightweight design, optimized battery lasting for up to 140 gaming hours, and more.
    See all Gaming Mice
    Top comment

    "If something like that won't bother you, it's an EXCELLENT mouse and probably 5 stars! No worries about double clicking with the optical switches, long battery life, and a great shape (fit my hands like a glove)....The last mouse youll buy...I swapped out various mice this year between the pro & x 903 this is the most comfortable mouse ive ever bought. "

    See all customer reviews

    Product Description

    G502 X LIGHTSPEED, the latest version of Logitech’s most popular gaming mouse, combines a legacy of performance with the most advanced gaming technologies. G502 X also introduces hybrid optical-mechanical LIGHTFORCE switches for the primary left and right buttons. Complete with updated LIGHTSPEED wireless with 68 percent faster response rate, HERO 25K sub-micron sensor, reversible and removable DPI-shift button, redesigned scroll wheel with dual hyper-fast and precise ratchet modes, thin-wall molding and lightweight design, optimized battery lasting for up to 140 gaming hours, and more.
    See all Gaming Mice
    See all Gaming Mice
  7. Logitech - Signature M650 L Full-size Wireless Scroll Mouse with Silent Clicks - Red - Front_Zoom
    Top comment

    "Wireless mouse...Just picked it up of the shelf and didn’t realize they had ones for left handed and right handed people. Glad to see that! ...Awesome Mouse!...Love it! I wore out the left click of my last mouse, and this one is one of the best I've ever used."

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    Product Description

    Upgrade to smarter scrolling, better comfort, and more productivity with the Signature M650 L. The versatile mouse features an adaptive scroll SmartWheel that delivers line-by-line precision, and auto-switches to super-fast free spin mode with the flick of a finger. A choice of sizes for smaller, larger and left hands means there's a perfect fit for anyone. Seamless wireless connectivity, customizable side buttons, and a comfort shape keep you comfortably and productive hour after hour. Logitech’s SilentTouch technology delivers silent clicks to keep you focused – while the up to 24-month battery life and universal operating system compatibility ensure hassle-free performance.
    See all Wireless & Bluetooth Mice
    Top comment

    "Wireless mouse...Just picked it up of the shelf and didn’t realize they had ones for left handed and right handed people. Glad to see that! ...Awesome Mouse!...Love it! I wore out the left click of my last mouse, and this one is one of the best I've ever used."

    See all customer reviews

    Product Description

    Upgrade to smarter scrolling, better comfort, and more productivity with the Signature M650 L. The versatile mouse features an adaptive scroll SmartWheel that delivers line-by-line precision, and auto-switches to super-fast free spin mode with the flick of a finger. A choice of sizes for smaller, larger and left hands means there's a perfect fit for anyone. Seamless wireless connectivity, customizable side buttons, and a comfort shape keep you comfortably and productive hour after hour. Logitech’s SilentTouch technology delivers silent clicks to keep you focused – while the up to 24-month battery life and universal operating system compatibility ensure hassle-free performance.
    See all Wireless & Bluetooth Mice
    See all Wireless & Bluetooth Mice
  8. Logitech - G502 X Wired USB Gaming Mouse with HERO 25K Sensor - Black - Front_Zoom
    Top comment

    "Great Gaming Mouse...Amazing upgrade from the original 502 series of mice...Like most mice it works great when it is new, but in only 6 months this thing started messing up. "

    See all customer reviews

    Product Description

    G502 X, the latest version of Logitech’s most popular gaming mouse, combines a legacy of performance with the most advanced gaming technologies. G502 X also introduces hybrid optical-mechanical LIGHTFORCE switches for the primary left and right buttons. With HERO 25K sub-micron sensor, reversible and removable DPI-shift button, redesigned scroll wheel with dual hyper-fast and precise ratchet modes, thin-wall molding and lightweight design.
    See all Gaming Mice
    Top comment

    "Great Gaming Mouse...Amazing upgrade from the original 502 series of mice...Like most mice it works great when it is new, but in only 6 months this thing started messing up. "

    See all customer reviews

    Product Description

    G502 X, the latest version of Logitech’s most popular gaming mouse, combines a legacy of performance with the most advanced gaming technologies. G502 X also introduces hybrid optical-mechanical LIGHTFORCE switches for the primary left and right buttons. With HERO 25K sub-micron sensor, reversible and removable DPI-shift button, redesigned scroll wheel with dual hyper-fast and precise ratchet modes, thin-wall molding and lightweight design.
    See all Gaming Mice
    See all Gaming Mice
  9. Logitech - M310 Wireless Optical Ambidextrous Mouse - Black - Front_Zoom
    Top comment

    "It makes an even bigger difference because I am right-handed and my husband is left-handed and we don't have to worry about the wire when switching the mouse from the left side of the computer to the right, depending on who is using it....It's a mouse....It's a cheap mouse that does mouse things. minimum required characters left: 8"

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    Product Description

    Logitech M310 Wireless Mouse is an easy-to-use, full-size mouse that feels just right. Feel comfortable for hours on end - in your right or left hand - thanks to its contoured, ambidextrous design with soft rubber side grips. M310 comes with a plug-and-forget nano USB receiver that is small enough to stay in your USB port so you won't lose it no matter where you take your laptop. Navigating on your PC or Macbook is simple, with smooth, responsive tracking and Logitech Advanced 2.4 GHz wireless connectivity. For hassle-free use and extreme reliability and durability, choose M310 wireless mouse.
    See all Wireless & Bluetooth Mice
    Top comment

    "It makes an even bigger difference because I am right-handed and my husband is left-handed and we don't have to worry about the wire when switching the mouse from the left side of the computer to the right, depending on who is using it....It's a mouse....It's a cheap mouse that does mouse things. minimum required characters left: 8"

    See all customer reviews

    Product Description

    Logitech M310 Wireless Mouse is an easy-to-use, full-size mouse that feels just right. Feel comfortable for hours on end - in your right or left hand - thanks to its contoured, ambidextrous design with soft rubber side grips. M310 comes with a plug-and-forget nano USB receiver that is small enough to stay in your USB port so you won't lose it no matter where you take your laptop. Navigating on your PC or Macbook is simple, with smooth, responsive tracking and Logitech Advanced 2.4 GHz wireless connectivity. For hassle-free use and extreme reliability and durability, choose M310 wireless mouse.
    See all Wireless & Bluetooth Mice
    See all Wireless & Bluetooth Mice
  10. Logitech - M310 Wireless Optical Ambidextrous Mouse - Silver - Front_Zoom
    Top comment

    "Logitech Wireless mouse...Can be for left or right handed persons. We selected this mouse as I my husband and I are right handed and our daughter is left handed....Excellent portable mouse...I'm left-handed so most mice don't work for me. This one does."

    See all customer reviews

    Product Description

    Logitech M310 Wireless Mouse is an easy-to-use, full-size mouse that feels just right. Feel comfortable for hours on end - in your right or left hand - thanks to its contoured, ambidextrous design with soft rubber side grips. M310 comes with a plug-and-forget nano USB receiver that is small enough to stay in your USB port so you won't lose it no matter where you take your laptop. Navigating on your PC or Macbook is simple, with smooth, responsive tracking and Logitech Advanced 2.4 GHz wireless connectivity. For hassle-free use and extreme reliability and durability, choose M310 wireless mouse.
    See all Wireless & Bluetooth Mice
    Top comment

    "Logitech Wireless mouse...Can be for left or right handed persons. We selected this mouse as I my husband and I are right handed and our daughter is left handed....Excellent portable mouse...I'm left-handed so most mice don't work for me. This one does."

    See all customer reviews

    Product Description

    Logitech M310 Wireless Mouse is an easy-to-use, full-size mouse that feels just right. Feel comfortable for hours on end - in your right or left hand - thanks to its contoured, ambidextrous design with soft rubber side grips. M310 comes with a plug-and-forget nano USB receiver that is small enough to stay in your USB port so you won't lose it no matter where you take your laptop. Navigating on your PC or Macbook is simple, with smooth, responsive tracking and Logitech Advanced 2.4 GHz wireless connectivity. For hassle-free use and extreme reliability and durability, choose M310 wireless mouse.
    See all Wireless & Bluetooth Mice
    See all Wireless & Bluetooth Mice
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