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Left-handed Wireless Mouse

If you're left-handed, finding a mouse that feels natural can be tricky. Most mice are designed for righties, but there are some left-handed mice that offer comfort and control for your left hand. Browse the top-ranked list of left-handed wireless mice below along with associated reviews and opinions.

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  1. Logitech - M310 Wireless Optical Ambidextrous Mouse - Wireless - Black

    SKU: J7H7ZYJ4LY

    Product Description

    An ergonomic black wireless mouse with ambidextrous design, soft rubber grips, and responsive optical tracking.
    See all Wireless & Bluetooth Mice
    Your price for this item is $17.99
    Save $5
    The previous price was $22.99

  2. Logitech - M310 Wireless Optical Ambidextrous Mouse - Wireless - Silver

    SKU: J7H7ZLV3V9

    Product Description

    A wireless silver mouse with ambidextrous ergonomic design, soft rubber grips, and smooth, responsive tracking.
    See all Mice
    Your price for this item is $17.99
    Save $5
    The previous price was $22.99

  3. Logitech - Lift Vertical Wireless Optical Ergonomic Mouse with 4 Customizable Buttons - Wireless - Graphite

    SKU: J7H7ZY3F9C

    Product Description

    An ergonomic graphite wireless mouse with quiet clicks, 4 customizable buttons, and a comfortable vertical design.
    See all Mice
    Your price for this item is $69.99
    Save $10
    The previous price was $79.99

  4. Logitech - Lift Vertical Wireless Optical Ergonomic Mouse with 4 Customizable Buttons - Wireless - Rose

    SKU: J7H7ZY3F9H

    Great little mouse...I love it! Works great I’m left handed and it fits my hand perfectly...Finally a pain-free mouse option...Phenomenal mouse. Much improved multiple musculoskeletal and nerve impingement...

    Product Description

    A wireless ergonomic mouse in rose with quiet clicks, 4 customizable buttons, and a comfortable vertical design.
    See all Mice
    Your price for this item is $69.99
    Save $10
    The previous price was $79.99

  5. Logitech - M196 Lightweight Bluetooth Wireless Optical Mouse Compact 3-Button Ambidextrous Mouse with Smooth Tracking - Wireless - Sand

    SKU: J7H7ZYLJYY

    Product Description

    A compact sand-colored wireless mouse featuring Bluetooth connectivity, ambidextrous design, and smooth optical tracking.
    See all Wireless & Bluetooth Mice
    Your price for this item is $12.99

  6. Logitech - Lift for Business Vertical Ergonomic Left Handed Wireless Mouse - Wireless - Graphite

    SKU: J7H7ZY3FP3

    Product Description

    An ergonomic left-handed wireless mouse in graphite, designed for comfort, security, and all-day productivity.
    See all Wireless & Bluetooth Mice
    Your price for this item is $79.99

  7. Logitech - M310 Wireless Optical Ambidextrous Mouse - Wireless - Flame Red

    SKU: J7H7ZLV5SQ

    Product Description

    A wireless, ambidextrous mouse in flame red with ergonomic design, soft rubber grips, and smooth tracking.
    See all Mice
    Your price for this item is $17.99
    Save $5
    The previous price was $22.99

  8. Best Buy essentials™ - Lightweight Bluetooth Optical Standard Ambidextrous Mouse with 6-Button - Wireless - Black

    SKU: J2FPJKSK2J

    I am right handed, but this mouse is ambidextrous, meaning it can be for both left or right handed people. ...Nice mouse...Great mouse for use with my laptop. I am left handed so it does fit me comfortably...

    Product Description

    A wireless black Bluetooth mouse with six buttons, ambidextrous design, and precise 1600 DPI optical tracking.
    See all Mice
    Your price for this item is $16.99

  9. Logitech - G903 LIGHTSPEED Wireless Optical Gaming Ambidextrous Mouse with RGB Lighting - Wireless - Black

    SKU: J7H7ZYX6Y6

    Product Description

    An ambidextrous black wireless gaming mouse featuring 11 programmable buttons, RGB lighting, and precise optical tracking.
    See all Gaming Mice
    Your price for this item is $114.99
    Save $25
    The previous price was $139.99

  10. Microsoft - Surface Bluetooth Optical Ambidextrous Mouse - Wireless - Silver

    SKU: J3ZKKZKRFQ

    Works great with my new windows laptop! I am left handed but have gotten used to right hand mouse, so it is perfect for me when I want to switch it up....I don't know why I like this mouse so much, but...

    Product Description

    A wireless silver mouse with Bluetooth connectivity, ambidextrous design, and a comfortable metal scroll wheel.
    See all Mice
    Your price for this item is $59.99
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In-store pricing may vary. Prices and offers are subject to change. © 2026 Best Buy. All rights reserved. BEST BUY, the BEST BUY logo, the tag design, and MY BEST BUY are trademarks of Best Buy and its affiliated companies.