A:Answer Hi Kait,
I just submitted a review less than an hour ago for my very similar situation. The answer is yes, it should be very easy for your great grandma to use. She should be able to use it pretty much with voice commands. If she's gonna make the calls herself, she can still do that with voice commands only, as long as she knows how you set up the contact list of names in her phone directory. That's what Alexa will use to make the calls. Or, if she knows the person's phone number, she can spell it out to Alexa. Either way, she shouldn't need to do much on the touchscreen, unless she wants to. If Alexa gets lost in the process, which Alexa does sometimes, all your great grandma will need to say is "Alexa, home" and she can start over.
My setup for my mom's Echo Show 8 was a little complicated because she doesn't have a smartphone that I could link to the Amazon and Alexa accounts (both free) that had to be created. I just read several articles and watched some YouTube videos to figure out what to do. If your great grandma has a smart phone, then the setup process should be a whole lot easier than what I describe in my review.
Good Luck!
PS - the optional stand will probably be worthwhile for your great grandma so that she can tilt the display to suit her desired viewing angle
