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No it will not. This lens is only compatible with RF mount cameras (EOS R series cameras- mirrorless). The Canon Rebel T2i is an EF/EF-S mount camera. I would recommend that you upgrade to an EOS R series camera and with the help of the mount adapter EF-EOS R you can use all your EF/EF-S lenses on your new EOS R series camera in addition to all the previous and future RF/RF-S lenses that come out.
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