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The compatibility depends on the functionality and the labeling of the wires. Nest Thermostat E is compatible with 85% of 24V systems. You can take a look at the following article to determine if your system is compatible with Nest thermostats : https://support.google.com/googlenest/answer/9246656 You can also reach out to a local Nest Pro to assist you here : https://nest.com/#pro
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