A:Answer In my limited experience, yes. I purchased Avery business card stock (10-cards per 8.5x11" sheet) and used that. The front printed just fine. My business card design is double-sided, and when printing the back of the card, the bottom (2) cards smudged a little about half-way down. I don't know if it's because I didn't let the card stock cool down enough prior to printing the back or why that happened. The other (8) cards were great. I will also note, since my intent was only to print the (1) sheet, I only put the single sheet in the supply tray - I didn't have a whole supply tray of card stock for the printer to have to load one sheet at a time. Thus I don't know if that would be any issue. (However, I'm thinking not.) This printer has been very easy to use so far (2 weeks of use), and I do recommend it. HP software to run the various print, scan, fax functions is very easy to use.