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Apple TV, yes. I do not know about Amazon fire stick. Check here: https://support.myharmony.com/en-us/compatibility
Sorry, there was a problem. Please try again later.Sorry, I'm not sure. I will say that it has a huge number of products it does support and I had no problem finding my equipment. It has to lock onto bluetooth enabled devices. If firestick and apple TV can be accessed via your phone or other remote device, I believe that this remote will have no problem finding it. Again, I have no experience with either Apple TV or Firestick. I don't want to lead you astray here.
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