A:Answer Absolutely. I have a new m.2 SSD on the way. The Intel app on the computer shows room for five more drives but I don't know where you would store them all. It is also upgradable to 128 GB 2933MHz ram (four 32GB sticks). There is a second PCI slot but it's basically useless because of the size of the GPU. You would need a different case and a vertical installation adapter to even think about opening up room for the second PCI slot. I believe the board will also run any of the gen 10 Intel CPUs. You can look the motherboard up on CDW and get the full specs of the MSI MAG B460M MORTAR WIFI motherboard but below is an excerpt showing the processor and ram compatability.
Mainboard
Form Factor :Micro ATX
Processor Socket :LGA1200 Socket
Compatible Processors Comments :Supports 10th Generation Intel Core / Pentium Gold / Celeron
Chipset Type :Intel B460
Supported RAM Technology :DDR4 SDRAM
Supported RAM Speed :2933 MHz, 2666 MHz
Supported RAM Integrity Check :Non-ECC
Supported RAM (Registered or Buffered) :Unbuffered
RAM Slots :4 DIMM slots
Power Connectors :24-pin main power connector, 8-pin ATX12V connector