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No, the CS50 is meant for use with a desk phone only. Here are some similar headset systems that can be used with a PC: Savi 400 Series: http://www.plantronics.com/us/product/savi-400 Savi 700 Series: http://www.plantronics.com/us/product/savi-700 Thank you for contacting us. Plantronics Customer Support 1-855-765-7878
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