A:AnswerI don’t have any Samsung products, but it does work with my Apple TV 4K, my Sony blue ray, Toshiba and LG players and my Panasonic TV. Everything that it said it would work with, it does and the pairing is pretty straightforward and easy. If it says it will pair with Samsung, then I don’t see why it wouldn’t work. Hope this is helpful.
A:AnswerIt should work but just be aware that you may not get all functions from the remote as compared to the original remotes. As an example I could not get into my TV's tool menu and thus I could not get to the sleep timer which I use all the time. I suspect this will happen with other devices also. You will get the basic functions only.
As far as other devices such as the Roku, it will work but be aware if you have the earlier Roku that had the RF remote, the range with this remote will be limited as this remote is IR only and thus is line of sight. You have to be directly pointing at the device for it to work.
I have discovered that unfortunately, unless you get the real expensive remotes for over 200 dollars which you can program, these remotes are compromises at best.