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yes but make sure to install it in the M.2 slot with the heat sink as this is a PCIe 4.0 drive, where as the M.2 second slot on your motherboard is only PCIe 3.0, so if you were to use that slot you'd bottle neck your new drive unneccessarily!
Sorry, there was a problem. Please try again later.Larry: Yes. The MSI B550 motherboard supports M.2 PCIe NVMe Gen 4 SSD, which makes this drive compatible. - Samsung Memory
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