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Comfortable Wireless Mouse

If you're a heavy computer user, you'll want a mouse that's comfortable as well as easy to use. And if you're a gamer, you'll want one that's responsive and accurate. The best mice for most people offer multiple buttons and adjustable sensitivity. They're also designed to be comfortable in your hand and to prevent hand cramps or pain when used for long periods. Browse the top-ranked list of comfortable wireless mice below along with associated reviews and opinions.   

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  1. Logitech - M310 Wireless Optical Ambidextrous Mouse - Wireless - Silver

    SKU: J7H7ZLV3V9

    Product Description

    A wireless silver mouse with ambidextrous ergonomic design, soft rubber grips, and smooth, responsive tracking.
    See all Mice
    Your price for this item is $18.99
    Save $4
    The previous price was $22.99

  2. Logitech - M310 Wireless Optical Ambidextrous Mouse - Wireless - Peacock Blue

    SKU: J7H7ZLVLQJ

    Product Description

    An ergonomic, ambidextrous wireless mouse in peacock blue with soft rubber grips and smooth tracking.
    See all Mice
    Your price for this item is $18.99
    Save $4
    The previous price was $22.99

  3. Logitech - M317 Wireless Optical Mouse - Wireless - Black

    SKU: J7H7ZY742Z

    Product Description

    A compact black wireless mouse featuring a contoured design, soft rubber grips, and plug-and-play convenience.
    See all Wireless & Bluetooth Mice
    Your price for this item is $22.99

  4. Logitech - M317 Wireless Optical Mouse - Wireless - Blue

    SKU: J7H7ZY7YLJ

    Product Description

    A compact blue wireless mouse featuring a contoured design, soft rubber grips, and ambidextrous comfort.
    See all Wireless & Bluetooth Mice
    Your price for this item is $22.99

  5. Logitech - Lift for Mac Wireless Bluetooth Optical Ergonomic Mouse with 4 Customizable Buttons - Wireless - Off-White

    SKU: J7H7ZY3FQH

    Product Description

    An ergonomic off-white Bluetooth mouse with quiet clicks, four customizable buttons, and a vertical design for comfort.
    See all Mice
    Your price for this item is $81.99

  6. Logitech - ERGO M575 S Wireless Ergonomic Trackball Mouse - Wireless - White

    SKU: J7H7ZY8FZJ

    Excellent mouse, I got it for a friend who's on the PC all day at work, he told me it works great, links up fast to other Logitech devices, and its very comfortable....The wireless feature is handy....

    Product Description

    An ergonomic white wireless trackball mouse offering thumb control, Bluetooth connectivity, and reduced forearm strain.
    See all Mice
    Your price for this item is $44.99
    Save $5
    The previous price was $49.99

  7. Logitech - ERGO M575 S Wireless Ergonomic Trackball Mouse - Wireless - Black

    SKU: J7H7ZY8FK9

    Product Description

    An ergonomic black wireless trackball mouse offering smooth thumb control, Bluetooth connectivity, and reduced muscle strain.
    See all Mice
    Your price for this item is $44.99
    Save $5
    The previous price was $49.99

  8. Logitech - M170 Wireless Compact Optical Ambidextrous Mouse - Wireless - Black

    SKU: J7H7ZYCFT3

    comfortable small mouse...Small and light weight. Comfortable and easy to use....Comfortable...No lag time. Feels comfortable in hand.

    Product Description

    A compact, ambidextrous black wireless mouse offering plug-and-play convenience and up to 12-month battery life.
    See all Mice
    Your price for this item is $11.99
    Save $3
    The previous price was $14.99

  9. CORSAIR - IRONCLAW WIRELESS SE FPS/MOBA/MMO Optical Gaming Mouse - Wireless - Black

    SKU: J39TSCHV4H

    Product Description

    A black wireless gaming mouse featuring a 26k DPI sensor, tri-mode connectivity, and textured grips.
    See all Gaming Mice
    Your price for this item is $89.99

  10. Pulsar - X2H Mini Wireless Gaming Mouse - Wireless - Superclear

    SKU: BGWYZZGHL2

    Product Description

    A wireless gaming mouse with a translucent black shell, red accents, and a lightweight, comfortable grip.
    See all Gaming Mice
    Your price for this item is $99.99
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In-store pricing may vary. Prices and offers are subject to change. © 2026 Best Buy. All rights reserved. BEST BUY, the BEST BUY logo, the tag design, and MY BEST BUY are trademarks of Best Buy and its affiliated companies.