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The PCIe interface on this desktop is: One PCI Express x16 slot (PCIe V3.0) One PCI Express x1 slot (PCIe V2.0) Two mini-PCIe M.2 slot (PCIe V3.0) Acer has not tested the GTX 1080, but this ships with a 300W power supply so we suggest you check the system requirements of the GPU you want to install.
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