The Nest Thermostat (2020) comes with a 6 cm color LCD with 240x320 resolution, and mirrored glass finish. It provides more wiring terminals (10) that work with most 24V heating and cooling systems, including furnaces, air conditioners, boilers, and heat pumps with either forced air or radiant delivery. On the other hand, the Nest Thermostat E comes with polycarbonate, ceramic-feel finished ring with a frosted display that works with fewer (86%) 24V heating and cooling systems.
While both Nest thermostat models work with most two-stage heating and two-stage cooling systems, we recommend checking the Compatibility Checker on our Google Nest support site to verify if your system is compatible. You can also take a look at the following support article for the complete technical specifications of the Nest thermostats: https://support.google.com/googlenest/answer/9230098