A:Answer Hi there,
The case shouldn't be an issue for an RTX 4080. However, each GPU may vary in exact size based on the brand/manufacturer you purchase form. In addition, the PSU included in this PC is a 700 Watt power supply that is optimized around the RTX 4070.
If you plan to upgrade to an RTX 4080, you'll need a 750 Watt PSU at minimum (we suggest 800W in case of a more powerful CPU too). NVIDIA's own website will list suggested specs for your build.