A:Answer You want to run your subs wired in series, this will raise the ohm rating of your amp making it safer for your 12 inch subs. I would start with your gain level at a quarter of its maximum gain level, turn up your system and listen closely to your subs, make sure they are producing clean bass, if they sound clean then try turning your gain up just a little more, if they start to pop instead of bump then you know to turn your gain back down, enjoy!