A:Answer Hello owensantos5ismytwitch! If your MSI Optix Monitor has a 3.5mm aux port at the back, and your console (Xbox or PS5) is connected to your monitor via the HDMI port, then yes, you'll be goot to use the z213 2.0 Multimedia Speaker System by connecting its 3.5mm AUX cable to the 3.5mm port on your monitor. - Mathieu from Logitech