Depending on which model Honda you are driving, it may work for you. If it has an auxiliary port connection in your car (typically the base/lower trim lines), you can plug the player's earphone jack into the auxiliary port to play your music through your speakers. If it does not have the auxiliary jack, you cannot connect it since the player does not support blue tooth. I don't know if the player will play when connected to the USB port for power/charging, so you may have to play your music off the player's battery.
Hope that helps!