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Thanks for your question. The Canvio Connect II hard drives are all compatible with Windows Vista. They are also all compatible with USB 2.0 and USB 3.0.
Sorry, there was a problem. Please try again later.Any HDD more than 2 TB does not work on Windows XP. Everything works on Windows 7. I do not know if Vista is more similar to XP or 7, so I recommend you dump Vista for something better -- i have heard nothing but bad things about it. -- it was a total mistake by Microsoft.
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