A:Answer yes it will, but.....You'll need parts to install this JVC in your Mercedes-Benz ML350 also keep in mind that the In this vehicle, the functions of the yellow and red wires in the wiring harness are reversed. The yellow wire supplies ignition power, and the red wire supplies constant power.also when you replace your factory radio, you'll lose the vehicle's factory navigation and telephone features if equipped hope that helps.
