A:AnswerHello Ed! Absolutely, the Signature M650 L Full-size Wireless Scroll Mouse with Silent Clicks will work on macOS 10.15 or later vis Bluetooth, or macOS 10.10 or later via it's Bolt USB Receiver. - Mathieu from Logitech
A:AnswerDownload the software from Logitech for the mouse. On Mac's, it creates an app which you'll need to open. Once the app is open, click on the image of your mouse, then click on each of the side buttons and choose what you'd like to have that button do.