A:Answer It will work good with the pci express 16 ver 2.0. I have it working on my ver 2.0 slot and it is good. However, the power supply is probably not big enough. The card comes with a 6pin cable to 4pin molex adapter for more power, so I am guessing 300w is absolutely bare minimum or just not big enough. Also, HP has a history of proprietary power supply connectors and if so, you may not be able to replace it.