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Thumb Rest Mouse

A thumb rest mouse is a type of computer mouse that has a small, flat piece of plastic or rubber that fits between the thumb and the rest of the hand. It is designed to reduce the stress on the hand and wrist caused by holding a standard mouse.  Browse the top-ranked list of thumb rest mice below along with associated reviews and opinions. 

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  1. Logitech - ERGO M575 S Wireless Ergonomic Trackball Mouse - Wireless - White

    SKU: J7H7ZY8FZJ

    Ergonomic mouse...It is more comfortable than other mice. It does not have to move around on the desk. ...Moving the trackball with my thumb seems natural and all my fingers fall into place.

    Product Description

    An ergonomic white wireless trackball mouse offering thumb control, Bluetooth connectivity, and reduced forearm strain.
    See all Mice
    Your price for this item is $39.99
    Save $10
    The previous price was $49.99

  2. Logitech - ERGO M575 S Wireless Ergonomic Trackball Mouse - Wireless - Black

    SKU: J7H7ZY8FK9

    Product Description

    An ergonomic black wireless trackball mouse offering smooth thumb control, Bluetooth connectivity, and reduced muscle strain.
    See all Mice
    Your price for this item is $39.99
    Save $10
    The previous price was $49.99

  3. Logitech - MX ERGO S PLUS Wireless Ergonomic Trackball Mouse with 6 Programmable Buttons - Wireless - Graphite

    SKU: J7H7ZYGRHW

    Product Description

    An ergonomic wireless trackball mouse in graphite with 6 programmable buttons and dual Bluetooth connectivity.
    See all Mice
    Your price for this item is $99.99
    Save $20
    The previous price was $119.99

  4. Glorious - Model I 2 Ultra Lightweight Wireless Optical Gaming Mouse with 9 Programmable Buttons - Wireless - Matte Black

    SKU: J3GWJX2PRW

    Great light weight mouse....Older gamer here with wide hands. love the weight and the thumb rest of this mouse. side buttons seem a little off but other than that no complaints....Great Ergo Mouse...Really...

    Product Description

    A matte black, ultra-lightweight wireless gaming mouse featuring 9 programmable buttons and a 26K optical sensor.
    See all Gaming Mice
    Your price for this item is $79.99
    Save $20
    The previous price was $99.99

  5. Logitech - ERGO M575 Wireless Trackball Ergonomic Mouse for Business - Wireless - Graphite

    SKU: J7H7ZY3TKS

    Product Description

    An ergonomic graphite wireless trackball mouse with smooth thumb control, customizable buttons, and quiet clicks.
    See all Wireless & Bluetooth Mice
    Your price for this item is $44.99
    Save $5
    The previous price was $49.99

  6. Logitech - Lift Vertical Wireless Optical Ergonomic Mouse with 4 Customizable Buttons - Wireless - Graphite

    SKU: J7H7ZY3F9C

    Product Description

    An ergonomic graphite wireless mouse with quiet clicks, 4 customizable buttons, and a comfortable vertical design.
    See all Mice
    Your price for this item is $69.99
    Save $10
    The previous price was $79.99

  7. JLab - JBuds Ergonomic Wireless Mouse - Wireless - Black

    SKU: J3GW8XZ6LZ

    Relief for thumb arthritis...I have thumb arthritis and using a regular mouse was starting to make my thumbs ache … I was very hesitant on getting a bulky mouse like this but I was desperate and will...

    Product Description

    An ergonomic black wireless mouse featuring seven programmable buttons, Bluetooth connectivity, and a contoured vertical design.
    See all Mice
    Your price for this item is $33.99
    Save $6
    The previous price was $39.99

  8. Razer - Tartarus V2 Wired Gaming Mecha-Membrane Keypad with Chroma Back Lighting for PC - Black

    SKU: J3L9H24RTP

    Product Description

    A black gaming keypad featuring 32 programmable keys, mecha-membrane switches, Chroma RGB lighting, and palm rest.
    See all PC Gaming Controllers
    Your price for this item is $79.99

  9. Logitech - Wave Keys and Lift Vertical Mouse Wireless Ergonomic Keyboard and Mouse Bundle with Cushioned Palm Rest - Graphite

    SKU: J7H7ZYL8SY

    Product Description

    An ergonomic graphite wireless keyboard and vertical mouse bundle with cushioned palm rest, ideal for comfort.
    See all Keyboard & Mouse Combos
    Your price for this item is $99.99
    Save $20
    The previous price was $119.99

  10. Logitech - Wave Keys and Lift Vertical Mouse Wireless Ergonomic Keyboard and Mouse Bundle with Cushioned Palm Rest - Off-White

    SKU: J7H7ZYL8PP

    Product Description

    An off-white wireless ergonomic keyboard and vertical mouse bundle with cushioned palm rest for all-day comfort.
    See all Keyboard & Mouse Combos
    Your price for this item is $99.99
    Save $20
    The previous price was $119.99
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In-store pricing may vary. Prices and offers are subject to change. © 2026 Best Buy. All rights reserved. BEST BUY, the BEST BUY logo, the tag design, and MY BEST BUY are trademarks of Best Buy and its affiliated companies.