A:Answer Yes, I believe so. We have the Roku Premiere plus the sideclick in our family room. I programmed the power button on sideclick to turn tv on/off, the ‘B’ button powers our Pioneer receiver on/off, The +/- buttons adjust volume through receiver (I also programmed the ^/¥ for volume too but those could be programmed for another device if needed). I programmed the ‘A’ button to power the DVD player however I’m not sure the other buttons will play, stop, fast forward or rewind. Could possibly program the up or down arrows to do 2 of those functions, I haven’t tried. This sideclick was easy to program and the only way I could figure out how to control our tv plus the receiver as our only audio source with 1 remote. I’m very happy with it!