A:Answer This is from my spouse, who just changed out an older Honeywell model for these (we have three of them):
The backing itself is different but the position of the screws that hold the case to the wall should be the same, ( ie no need to drill new holes)
Expect to connect 5 wires (for the most part they are color coded) a positive and negative for the AC and heater, and a thermostat reference.
Just in case they are not color coded, be prepared to label them BEFORE removing the old one. They should be connected to a small panel which has letters (Y, G, R, etc)
From me: The installation guide actually does say to remove the wires one by one and label them as you do. A sheet of sticky tags is included in the package for this purpose. I've included an illustration from the manual of what to do with the wires after that.