A:Answer Hello! In many ways, the MX Anywhere 2S Wireless Laser Mouse will be a big upgrade compared to the V450 Cordless Laser Mouse. Like the V450, the Anywhere 2S features a laser sensor, but its sensitivity goes up to 4000 DPI vs 1000 DPI only for the V450. Also, the Anywhere 2S is a rechargeable mouse vs 2AA batteries for the V450, so it's also less heavy than the V450, its got 8 buttons vs 3 for the V450, and it does both Bluetooth and Wireless vs just Wireless for the V450. - Mathieu from Logitech
