A:Answer Hello lisad. Epson ink bottles generally last about 1 to 2 years unopened, and once opened, they should be used within 6 to 12 months. It is best to store them upright at room temperature, away from direct sunlight, heat, and humidity to preserve print quality. If you don't print often, we recommend running a print head nozzle check every few days. Nozzle checks use very little ink, help monitor the print head’s condition, and allow you to perform a cleaning if needed. Regards, Kevin - The Epson Team.