A:Answer Yes, I use it with my Vizio M70-D3. It works great! I use it to control the Time Warner Cable DVR, Apple TV, Pioneer Elite AV receiver and Samsung Ultra Blu-ray player. The only thing I had any trouble setting up was the was the DVR. I had to set it up manually. The Harmony remote can operate all of the functions on the TV. I set four different functions; cable, Apple TV, Cast for streaming, and movie for the Blu-ray player.