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Ergonomic Mouse

If you spend a lot of time at your computer, an ergonomic mouse can help prevent or reduce the symptoms of repetitive strain injury (RSI). These mice are designed to fit your hand better and move more naturally, which can reduce the stress on your joints. Browse the top-ranked list of ergonomic mice below along with associated reviews and opinions. 

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  1. Adesso - Tru-Form Media WKB-1150CB Ergonomic Wireless Membrane Optical Keyboard and Mouse - Black

    SKU: J32P8779YL

    Product Description

    An ergonomic black wireless keyboard and mouse combo featuring split-key design, palm rest, and Bluetooth connectivity.
    See all Wireless & Bluetooth Keyboards
    Your price for this item is $62.99
    Save $11
    The previous price was $74.95

  2. JLab - JBuds Ergonomic Wireless Mouse - Wireless - Black

    SKU: J3GW8XZ6LZ

    The best ergonomic mouse I’ve ever had. Needed a new mouse for video editing and this was the best purchase....Very nice ergonomic mouse, and works as advertised. and you can use while its charging. ...Best...

    Product Description

    An ergonomic black wireless mouse featuring seven programmable buttons, Bluetooth connectivity, and a contoured vertical design.
    See all Mice
    Your price for this item is $33.99
    Save $6
    The previous price was $39.99

  3. Adesso - iMouse T40 - Wireless Programmable Ergonomic Trackball Mouse - Wireless - Black

    SKU: J32P877Q9J

    Product Description

    A wireless ergonomic trackball mouse in black with programmable buttons for comfortable, customizable control.
    See all Wireless & Bluetooth Mice
    Your price for this item is $52.00

  4. Adesso - iMouse Wireless Optical Ergonomic Mouse - Wireless - Black

    SKU: J32P877YZG

    Product Description

    An ergonomic black wireless mouse with vertical design, side navigation buttons, and adjustable DPI for comfort.
    See all Wireless & Bluetooth Mice
    Your price for this item is $51.18
    Save $0
    The previous price was $51.34

  5. Adesso - iMouse Wired Optical Ergonomic Mouse - Wired - Glossy black

    SKU: J32P877YZ7

    Product Description

    An ergonomic glossy black wired mouse with vertical design, adjustable DPI, and two side navigation buttons.
    See all USB & USB C Wired Mice
    Your price for this item is $41.49

  6. Adesso - Tru-Form Media WKB-1500GB Ergonomic Wireless Membrane Keyboard and Mouse - Black

    SKU: J32P877LZV

    Product Description

    An ergonomic black wireless keyboard and mouse set with split key zones, palm rest, and multimedia keys.
    See all Computer Keyboards
    Your price for this item is $71.49

  7. Adesso - iMouse T50 - Wireless Programmable Ergonomic Trackball Mouse - Wireless - Black

    SKU: J32P877R3Y

    Product Description

    A wireless black ergonomic trackball mouse featuring programmable buttons for comfortable, customizable control.
    See all Wireless & Bluetooth Mice
    Your price for this item is $59.91

  8. Delton - G18 Wireless Ergonomic Keyboard & Optical Vertical Mouse Combo (DKMKITERG18-WB) - Black

    SKU: J38PCKSPZQ

    Product Description

    An ergonomic black wireless keyboard and vertical mouse combo with plush wrist rest and five responsive buttons.
    See all Keyboard & Mouse Combos
    Your price for this item is $139.99

  9. Adesso - iMouse E30 Wireless Vertical Ergonomic Right-Handed Mouse, 6 Buttons, 4800 DPI - Wireless - Black

    SKU: J32P877SWK

    Product Description

    A wireless, ergonomic right-handed mouse in black with six buttons and up to 2400 DPI sensitivity.
    See all Wireless & Bluetooth Mice
    Your price for this item is $54.61
    Save $2
    The previous price was $56.69

  10. Delton - KB250&S38 Ergonomic Wired Keyboard and Mouse Combo, (DKME250S38-U) - Black

    SKU: J38PCKS9H5

    Product Description

    An ergonomic black wired keyboard and vertical mouse combo with wrist rest, adjustable DPI, and quiet operation.
    See all Keyboard & Mouse Combos
    Your price for this item is $109.99
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In-store pricing may vary. Prices and offers are subject to change. © 2026 Best Buy. All rights reserved. BEST BUY, the BEST BUY logo, the tag design, and MY BEST BUY are trademarks of Best Buy and its affiliated companies.