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Best Buy customers often prefer the following products when searching for ergonomic mouse.

If you spend a lot of time at your computer, an ergonomic mouse can help prevent or reduce the symptoms of repetitive strain injury (RSI). These mice are designed to fit your hand better and move more naturally, which can reduce the stress on your joints. Browse the top-ranked list of ergonomic mice below along with associated reviews and opinions.

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  1. Glorious - Model I 2 Ultra Lightweight Wireless Optical Gaming Mouse with 9 Programmable Buttons - Matte White - Front_Zoom

    Product Description

    Our most feature-rich lightweight mouse yet. 9 Programmable buttons with 2 customizable magnetic thumb buttons put you in control. Looking at the highly-comfortable ergonomic shape, it's hard to believe the Model I is only 75g. Quickly adapt the Model I to your playstyle with its modular side buttons. Two of the four thumb buttons are easily-swappable for a perfect fit in your hand. Or you can use the flat shape option to completely remove their usability. Up to nine unique combinations are available for you to try out. The Model I 2 becomes an extension of your arm for effortless control in all kinds of games. Its ergonomic body allows for a comfortable and confident grip that combats hand fatigue. Freely remap all the available buttons to your needs. Assign useful shortcuts, like instantly adjusting DPI by holding down a button, for custom control in games. Create and save up to three mouse profiles via Glorious CORE. Quickly switch between them to spend more time playing, less time tinkering.
    See all Gaming Mice

    Product Description

    Our most feature-rich lightweight mouse yet. 9 Programmable buttons with 2 customizable magnetic thumb buttons put you in control. Looking at the highly-comfortable ergonomic shape, it's hard to believe the Model I is only 75g. Quickly adapt the Model I to your playstyle with its modular side buttons. Two of the four thumb buttons are easily-swappable for a perfect fit in your hand. Or you can use the flat shape option to completely remove their usability. Up to nine unique combinations are available for you to try out. The Model I 2 becomes an extension of your arm for effortless control in all kinds of games. Its ergonomic body allows for a comfortable and confident grip that combats hand fatigue. Freely remap all the available buttons to your needs. Assign useful shortcuts, like instantly adjusting DPI by holding down a button, for custom control in games. Create and save up to three mouse profiles via Glorious CORE. Quickly switch between them to spend more time playing, less time tinkering.
    See all Gaming Mice
    See all Gaming Mice
  2. Razer - Basilisk V3 Wired Optical Gaming Mouse with Chroma RBG Lighting - White - Front_Zoom
    Top comment

    "[This review was collected as part of a promotion.] Mouse is very responsive during gaming. The ergonomic design is comfortable and the cycling colors are a nice touch. ...The other cool feature that he liked was the glowing lights underneath the mouse and the mouse wheel."

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    Product Description

    Create, control, and champion your playstyle with the new Razer Basilisk V3—the quintessential ergonomic gaming mouse for customized performance. With 10+1 programmable buttons, a dual-mode tilt scroll wheel, and a heavy dose of Razer Chroma RGB, it's time to light up the competition your way.
    See all Gaming Mice
    Top comment

    "[This review was collected as part of a promotion.] Mouse is very responsive during gaming. The ergonomic design is comfortable and the cycling colors are a nice touch. ...The other cool feature that he liked was the glowing lights underneath the mouse and the mouse wheel."

    See all customer reviews

    Product Description

    Create, control, and champion your playstyle with the new Razer Basilisk V3—the quintessential ergonomic gaming mouse for customized performance. With 10+1 programmable buttons, a dual-mode tilt scroll wheel, and a heavy dose of Razer Chroma RGB, it's time to light up the competition your way.
    See all Gaming Mice
    See all Gaming Mice
  3. Turtle Beach - Kone XP Air Wireless Optical Gaming Mouse with Charging Dock and AIMO RGB Lighting - White - Front_Zoom

    Product Description

    The Kone XP Air Wireless Ergonomic RGB Gaming Mouse is designed to put the functionality of actions and macros at your fingertips. Perfected through years of refinement, this mouse is equipped with 10 dedicated buttons plus left, right, and vertical scroll wheel click functionality to expand into 29 programmable inputs, thanks to the Easy-Shift[+] duplicator button. Want to take this mouse on the go? Switch between lag-free 2.4GHz wireless and Bluetooth® for the ultimate in versatility. Additionally, the Kone XP Air charging dock blends beautifully into your setup and comes equipped with a USB passthrough on the front for the 2.4GHz wireless adapter. To further the immersive RGB experience, the translucent shell and a 4D Wheel set the stage for the Kone XP Air’s 5 lighting zones, creating stunning lighting effects. AIMO lighting technology produces vibrant RGB lighting displays right out of the box or syncs with other compatible AIMO products. The Kone XP Air packs a performance punch with TITAN Optical Switches for lightspeed actuation and Owl-Eye 19K dpi optical sensor for precise movements. The heat-treated glides and a Phantom Flex charging cable to even further amplify your unrestricted gameplay, giving you the fastest, smoothest, and most precise experience possible.
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    Product Description

    The Kone XP Air Wireless Ergonomic RGB Gaming Mouse is designed to put the functionality of actions and macros at your fingertips. Perfected through years of refinement, this mouse is equipped with 10 dedicated buttons plus left, right, and vertical scroll wheel click functionality to expand into 29 programmable inputs, thanks to the Easy-Shift[+] duplicator button. Want to take this mouse on the go? Switch between lag-free 2.4GHz wireless and Bluetooth® for the ultimate in versatility. Additionally, the Kone XP Air charging dock blends beautifully into your setup and comes equipped with a USB passthrough on the front for the 2.4GHz wireless adapter. To further the immersive RGB experience, the translucent shell and a 4D Wheel set the stage for the Kone XP Air’s 5 lighting zones, creating stunning lighting effects. AIMO lighting technology produces vibrant RGB lighting displays right out of the box or syncs with other compatible AIMO products. The Kone XP Air packs a performance punch with TITAN Optical Switches for lightspeed actuation and Owl-Eye 19K dpi optical sensor for precise movements. The heat-treated glides and a Phantom Flex charging cable to even further amplify your unrestricted gameplay, giving you the fastest, smoothest, and most precise experience possible.
    See all Gaming Mice
    See all Gaming Mice
  4. Turtle Beach - Kone XP Air Wireless Optical Gaming Mouse with Charging Dock and AIMO RGB Lighting - Black - Front_Zoom

    Product Description

    The Kone XP Air Wireless Ergonomic RGB Gaming Mouse is designed to put the functionality of actions and macros at your fingertips. Perfected through years of refinement, this mouse is equipped with 10 dedicated buttons plus left, right, and vertical scroll wheel click functionality to expand into 29 programmable inputs, thanks to the Easy-Shift[+] duplicator button. Want to take this mouse on the go? Switch between lag-free 2.4GHz wireless and Bluetooth® for the ultimate in versatility. Additionally, the Kone XP Air charging dock blends beautifully into your setup and comes equipped with a USB passthrough on the front for the 2.4GHz wireless adapter. To further the immersive RGB experience, the translucent shell and a 4D Wheel set the stage for the Kone XP Air’s 5 lighting zones, creating stunning lighting effects. AIMO lighting technology produces vibrant RGB lighting displays right out of the box or syncs with other compatible AIMO products. The Kone XP Air packs a performance punch with TITAN Optical Switches for lightspeed actuation and Owl-Eye 19K dpi optical sensor for precise movements. The heat-treated glides and a Phantom Flex charging cable to even further amplify your unrestricted gameplay, giving you the fastest, smoothest, and most precise experience possible.
    See all Gaming Mice

    Product Description

    The Kone XP Air Wireless Ergonomic RGB Gaming Mouse is designed to put the functionality of actions and macros at your fingertips. Perfected through years of refinement, this mouse is equipped with 10 dedicated buttons plus left, right, and vertical scroll wheel click functionality to expand into 29 programmable inputs, thanks to the Easy-Shift[+] duplicator button. Want to take this mouse on the go? Switch between lag-free 2.4GHz wireless and Bluetooth® for the ultimate in versatility. Additionally, the Kone XP Air charging dock blends beautifully into your setup and comes equipped with a USB passthrough on the front for the 2.4GHz wireless adapter. To further the immersive RGB experience, the translucent shell and a 4D Wheel set the stage for the Kone XP Air’s 5 lighting zones, creating stunning lighting effects. AIMO lighting technology produces vibrant RGB lighting displays right out of the box or syncs with other compatible AIMO products. The Kone XP Air packs a performance punch with TITAN Optical Switches for lightspeed actuation and Owl-Eye 19K dpi optical sensor for precise movements. The heat-treated glides and a Phantom Flex charging cable to even further amplify your unrestricted gameplay, giving you the fastest, smoothest, and most precise experience possible.
    See all Gaming Mice
    See all Gaming Mice
  5. Insignia™ - Bluetooth 6-Button Ergonomic Mouse - Black - Front_Zoom
    Top comment

    "Insignia Bluetooth 6-Button Ergonomic Mouse...I really like this Insignia Bluetooth 6-Button Ergonomic Mouse. It is great quality an functions well....Insignia wireless mouse...This is the best ergonomic mouse I've used. Definitely recommend."

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    Product Description

    Whether you just got a new computer or are simply upgrading your current setup, you can’t go wrong with this Insignia NS-PM4EK6B24 Bluetooth 6-Button Ergonomic Mouse. It uses reliable Bluetooth technology to easily connect to your Windows, macOS, ChromeOS, iPadOS and Android systems. A sleek, ergonomic build is comfortable enough for everyday use, and 6 buttons provide plenty of simple, intuitive control options. Optical technology makes this mouse more than suitable for a variety of daily uses. Finally, a power switch and LED indicators help to preserve the battery life of your mouse. Upgrade your setup with this easy-to-use Insignia mouse.
    See all Mice & Keyboards
    Top comment

    "Insignia Bluetooth 6-Button Ergonomic Mouse...I really like this Insignia Bluetooth 6-Button Ergonomic Mouse. It is great quality an functions well....Insignia wireless mouse...This is the best ergonomic mouse I've used. Definitely recommend."

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    Product Description

    Whether you just got a new computer or are simply upgrading your current setup, you can’t go wrong with this Insignia NS-PM4EK6B24 Bluetooth 6-Button Ergonomic Mouse. It uses reliable Bluetooth technology to easily connect to your Windows, macOS, ChromeOS, iPadOS and Android systems. A sleek, ergonomic build is comfortable enough for everyday use, and 6 buttons provide plenty of simple, intuitive control options. Optical technology makes this mouse more than suitable for a variety of daily uses. Finally, a power switch and LED indicators help to preserve the battery life of your mouse. Upgrade your setup with this easy-to-use Insignia mouse.
    See all Mice & Keyboards
    See all Mice & Keyboards
  6. JLab - JBuds Ergonomic Wireless Mouse - Black - Front_Zoom

    Model: MJBERGORBLK82
    SKU: 6552790
    Top comment

    "Pretty Good ergonomic mouse...I like this, but not as much as other ergonomic mouse. Maybe it's a settings thing I need to work on. ...Excellent Ergonomic Mouse...To me this JBuds Ergonomic Wireless Mouse is great. I have not experience any of the pain in my wrist that I was experiencing before purchasing this mouse."

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    Product Description

    The JBuds Ergonomic Mouse offers blissful comfort with a personalized set-up for your favorite functions and tasks. With seven buttons, you have everything you need to reach working-from-home greatness, and everything you want to play your game, your way. The vertical design provides a natural angle for your wrist and hand, so switching between your favorite functions and your top devices is effortless.
    See all Wireless & Bluetooth Mice
    Top comment

    "Pretty Good ergonomic mouse...I like this, but not as much as other ergonomic mouse. Maybe it's a settings thing I need to work on. ...Excellent Ergonomic Mouse...To me this JBuds Ergonomic Wireless Mouse is great. I have not experience any of the pain in my wrist that I was experiencing before purchasing this mouse."

    See all customer reviews

    Product Description

    The JBuds Ergonomic Mouse offers blissful comfort with a personalized set-up for your favorite functions and tasks. With seven buttons, you have everything you need to reach working-from-home greatness, and everything you want to play your game, your way. The vertical design provides a natural angle for your wrist and hand, so switching between your favorite functions and your top devices is effortless.
    See all Wireless & Bluetooth Mice
    See all Wireless & Bluetooth Mice
  7. Glorious - Model I 2 Ultra Lightweight Wireless Optical Gaming Mouse with 9 Programmable Buttons - Matte Black - Front_Zoom
    Top comment

    "Great Ergo Mouse...Really like this mouse. Battery life coild be a little better but definitely am improvement over older Glorious mice....Great mouse!...My son also was amazed at the ergonomic shape of the mouse and the honeycomb design and with the weight of the mouse at just 74 grams!"

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    Product Description

    Elevate your gameplay like never before with the Model I 2 Wireless, the most comfortable gaming mouse in its class. Crafted with precision, this mouse combines an ergonomic design, ultra-lightweight construction, and a dedicated thumb rest, making it the perfect choice for gamers utilizing claw and palm grips. This next-gen mouse provides unrivaled comfort, allowing you to focus on your gameplay and achieve peak performance. The Model I 2 Wireless is a multi-genre mouse that caters to a wide range of gaming genres, including Battle Royale, MOBA, FPS, and more. Engineered with enhanced the BAMF 2.0 26K Optical Sensor and new Motion Sync technology, it ensures pixel-perfect tracking and flawless accuracy. Weighing a featherlight 75 grams, the Model I 2 Wireless offers lightning-fast speed and effortless maneuverability. The structural integrity has been vastly improved, while the redesigned buttons provide a satisfying click with each press, ensuring optimal comfort and responsiveness. With 9 programmable buttons at your fingertips, you can easily assign in-game actions, custom macros, and game-enhancing features to boost your gameplay. Tailor the shape of the mouse to your playstyle by swapping two of its side button positions with included alternate shapes; magnets make the process quick and easy. The Model I 2 Wireless provides an unrivaled gaming experience with its DPI Shift and Layer Shift features, allowing you to instantly adjust sensitivity and unlock a second programmable layer for even more customization. Enjoy extended gameplay with its impressive battery life and choose between 3 ways to play: 2.4GHz wireless for a strong connection, Bluetooth 5.2 LE for extended battery life, or wired mode for uninterrupted gameplay.
    See all Gaming Mice
    Top comment

    "Great Ergo Mouse...Really like this mouse. Battery life coild be a little better but definitely am improvement over older Glorious mice....Great mouse!...My son also was amazed at the ergonomic shape of the mouse and the honeycomb design and with the weight of the mouse at just 74 grams!"

    See all customer reviews

    Product Description

    Elevate your gameplay like never before with the Model I 2 Wireless, the most comfortable gaming mouse in its class. Crafted with precision, this mouse combines an ergonomic design, ultra-lightweight construction, and a dedicated thumb rest, making it the perfect choice for gamers utilizing claw and palm grips. This next-gen mouse provides unrivaled comfort, allowing you to focus on your gameplay and achieve peak performance. The Model I 2 Wireless is a multi-genre mouse that caters to a wide range of gaming genres, including Battle Royale, MOBA, FPS, and more. Engineered with enhanced the BAMF 2.0 26K Optical Sensor and new Motion Sync technology, it ensures pixel-perfect tracking and flawless accuracy. Weighing a featherlight 75 grams, the Model I 2 Wireless offers lightning-fast speed and effortless maneuverability. The structural integrity has been vastly improved, while the redesigned buttons provide a satisfying click with each press, ensuring optimal comfort and responsiveness. With 9 programmable buttons at your fingertips, you can easily assign in-game actions, custom macros, and game-enhancing features to boost your gameplay. Tailor the shape of the mouse to your playstyle by swapping two of its side button positions with included alternate shapes; magnets make the process quick and easy. The Model I 2 Wireless provides an unrivaled gaming experience with its DPI Shift and Layer Shift features, allowing you to instantly adjust sensitivity and unlock a second programmable layer for even more customization. Enjoy extended gameplay with its impressive battery life and choose between 3 ways to play: 2.4GHz wireless for a strong connection, Bluetooth 5.2 LE for extended battery life, or wired mode for uninterrupted gameplay.
    See all Gaming Mice
    See all Gaming Mice
  8. Glorious Model O 2 PRO Lightweight Wireless Gaming Mouse with Optical Switches - Black - Front_Zoom
    Top comment

    "This mouse comes in weighing at 58 grams to give a light feel to go along with its ergonomic feel. ...Everything is fantastic but the tracking of this mouse feels weord so here’s what I mean, the mice tracks upwards of 1mm above the mouse pad so that makes low sensitivity fps games really hard since it would completely mess up your aim and I can’t limit it to one dpi so I had to set all dpi to 800 since it would oddly choose a different present even though the dpi button is unbinded"

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    Product Description

    Designed for passionate gamers, this tournament-grade PRO mouse gives you a competitive advantage in fast-paced esports titles. Real gamers know that the lighter the mouse, the easier it is to aim with greater speed and precision. Weighing only 58 grams, the Model O 2 PRO is the lightest gaming mouse in its class.As a performance-focused, wireless gaming mouse, this device ensures that nothing holds your abilities back from victory. Its Glorious Optical Switches register click inputs 80% faster than standard mechanical, and with zero risk of double-clicking. This makes in-game actions like shooting feel more responsive and consistent. Moreover, its symmetrical shape makes it highly versatile and ideal for all grip styles.Its powerful sensor, BAMF 2.0 26K, features Motion Sync technology, which provides pixel-perfect tracking and allows for smoother and more accurate aiming. With the Model O 2 PRO, you can enjoy up to 80 hours of uninterrupted gameplay between charges. When it’s time to top up, you can also play while charging.
    See all Gaming Mice
    Top comment

    "This mouse comes in weighing at 58 grams to give a light feel to go along with its ergonomic feel. ...Everything is fantastic but the tracking of this mouse feels weord so here’s what I mean, the mice tracks upwards of 1mm above the mouse pad so that makes low sensitivity fps games really hard since it would completely mess up your aim and I can’t limit it to one dpi so I had to set all dpi to 800 since it would oddly choose a different present even though the dpi button is unbinded"

    See all customer reviews

    Product Description

    Designed for passionate gamers, this tournament-grade PRO mouse gives you a competitive advantage in fast-paced esports titles. Real gamers know that the lighter the mouse, the easier it is to aim with greater speed and precision. Weighing only 58 grams, the Model O 2 PRO is the lightest gaming mouse in its class.As a performance-focused, wireless gaming mouse, this device ensures that nothing holds your abilities back from victory. Its Glorious Optical Switches register click inputs 80% faster than standard mechanical, and with zero risk of double-clicking. This makes in-game actions like shooting feel more responsive and consistent. Moreover, its symmetrical shape makes it highly versatile and ideal for all grip styles.Its powerful sensor, BAMF 2.0 26K, features Motion Sync technology, which provides pixel-perfect tracking and allows for smoother and more accurate aiming. With the Model O 2 PRO, you can enjoy up to 80 hours of uninterrupted gameplay between charges. When it’s time to top up, you can also play while charging.
    See all Gaming Mice
    See all Gaming Mice
  9. Logitech - M240 Silent Wireless Ambidextrous Mouse - Graphite - Front_Zoom
    Top comment

    "Great wireless mouse....Comfortable, ergonomic design. Very quiet click, and easy gliding....Best mouse ever!...I recently dropped my Microsoft surface on concrete and ended up breaking the USB port, thus I could no longer use a mouse with a USB accessory/dongle. I went over to a Best Buy store to look at purchasing a new laptop, but just remembered prior to that purchase that they make mice that don’t require that dongle, so I was trying out different peripherals and purchased this mouse as well as a Microsoft surface mouse, which was coming in at $40 retail, the Microsoft mouse makes those hard clicks when you click anywhere on the screen, which was quite annoying, this mouse is freaking amazing. "

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    Product Description

    Meet the reliable Logitech M240 Silent Bluetooth Mouse that frees up your workspace. Pair and play with a fast, easy Bluetooth wireless connection; just seconds and you’re connected—no dongle or port required. Ultra quiet-mouse with 90% reduced click sound and same click feel eliminates noise and distractions for you and others around you. 18-month battery life with auto sleep, so you go longer between battery changes. Comfortable, travel-friendly slim mouse is small enough to toss in a bag; the ambidextrous design guides either your right or left hand into a natural position.
    See all Wireless & Bluetooth Mice
    Top comment

    "Great wireless mouse....Comfortable, ergonomic design. Very quiet click, and easy gliding....Best mouse ever!...I recently dropped my Microsoft surface on concrete and ended up breaking the USB port, thus I could no longer use a mouse with a USB accessory/dongle. I went over to a Best Buy store to look at purchasing a new laptop, but just remembered prior to that purchase that they make mice that don’t require that dongle, so I was trying out different peripherals and purchased this mouse as well as a Microsoft surface mouse, which was coming in at $40 retail, the Microsoft mouse makes those hard clicks when you click anywhere on the screen, which was quite annoying, this mouse is freaking amazing. "

    See all customer reviews

    Product Description

    Meet the reliable Logitech M240 Silent Bluetooth Mouse that frees up your workspace. Pair and play with a fast, easy Bluetooth wireless connection; just seconds and you’re connected—no dongle or port required. Ultra quiet-mouse with 90% reduced click sound and same click feel eliminates noise and distractions for you and others around you. 18-month battery life with auto sleep, so you go longer between battery changes. Comfortable, travel-friendly slim mouse is small enough to toss in a bag; the ambidextrous design guides either your right or left hand into a natural position.
    See all Wireless & Bluetooth Mice
    See all Wireless & Bluetooth Mice
  10. HP - X3000 G3 Wireless Optical Ambidextrous Mouse - Jet Black - Front_Zoom
    Top comment

    "Ergonomic mouse....Very ergonomic. Good price point. Got this for free with my HP laptop....Magical mouse not from Disney...Precise and ergonomic with excellent quality and control"

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    Product Description

    Lose the wire but not the power. Hit the road with a wireless mouse that looks as good as it feels, keeps you connected, and packs lasting power. Guaranteed by HP.
    See all Mice
    Top comment

    "Ergonomic mouse....Very ergonomic. Good price point. Got this for free with my HP laptop....Magical mouse not from Disney...Precise and ergonomic with excellent quality and control"

    See all customer reviews

    Product Description

    Lose the wire but not the power. Hit the road with a wireless mouse that looks as good as it feels, keeps you connected, and packs lasting power. Guaranteed by HP.
    See all Mice
    See all Mice
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